In an article, author is Algul, Oztekin, once mentioned the application of 129-64-6, COA of Formula: C9H8O3, Name is (3aR,4S,7R,7aS)-rel-3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione, molecular formula is C9H8O3, molecular weight is 164.158, MDL number is MFCD00151106, category is benzoxazole. Now introduce a scientific discovery about this category.
An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities
A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated forin vitrocytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that23, 26and29exhibit better activity against HepG2 and HeLa cancer cell lines. Compound23also showed good activity against A549, and A498 cancer cell lines. The analogs were further performed molecular docking studies against human cytochrome P450 2C8 monooxygenase enzyme, calculated some theoretical quantum parameters, ADMET descriptor and molecular electrostatic potential analysis. The strategy applied in this research work may act as a perspective for the rational design of potential anticancer drugs. Communicated by Ramaswamy H. Sarma
If you are interested in 129-64-6, you can contact me at any time and look forward to more communication. COA of Formula: C9H8O3.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem