Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 136630-39-2, Name is 2,7-Dibromo-9H-carbazole. In a document, author is Cheng, Ying, introducing its new discovery. COA of Formula: C12H7Br2N.
A benzoxazole compound as a novel MEK inhibitor for the treatment of RAS/RAF mutant cancer
Mutations in RAS/RAF occur in large portion of malignancies and are associated with aggressive clinical behaviors and poor prognosis. Therefore, we developed a novel benzoxazole compound (KZ-001) as a highly potent and selective MEK 1/2 inhibitor. Our efforts were focused on enhancing the activity of the known MEK inhibitor AZD6244 and overcoming the shortcomings existing in current MEK inhibitors. Here we show that compound KZ-001 exhibits approximately 30-fold greater inhibition against BRAF- and KRAS-mutant tumor cells than that of AZD6244. These results were also demonstrated using in vivo xenograft models. Furthermore, pharmacokinetics (PK) analysis was performed for KZ-001, and this compound showed good orally bioavailability (28%) and exposure (AUC(0-infinity) = 337 +/- 169 ng h/mL). To determine its potential clinical application, the synergistic effect of KZ-001 with other agents was investigated both in vitro and in vivo (xenograft models). KZ-001 exhibited synergistic anti-cancer effect in combination with BRAF inhibitor vemurafenib and a microtubule-stabilizing chemotherapeutic agent docetaxel. In addition, KZ-001 inhibited the MAPK pathway like known MEK inhibitors. In summary, KZ-001, a structurally novel benzoxazole compound, was developed as a MEK inhibitor that has potential for cancer treatment.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 136630-39-2 help many people in the next few years. COA of Formula: C12H7Br2N.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem