A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 345-92-6, Name is Bis(4-Fluorophenyl)methanone, molecular formula is C13H8F2O. In an article, author is El-Helby, Abdel-Ghany A.,once mentioned of 345-92-6, Computed Properties of https://www.ambeed.com/products/345-92-6.html.
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR-2 inhibitors
Novel series of benzoxazoles 4(a-f)-16 were designed, synthesized, and evaluated for anticancer activity against HepG2, HCT-116, and MCF-7 cells. HCT-116 was the most sensitive cell line to the influence of the new derivatives. In particular, compound 5(e) was found to be the most potent against HepG2, HCT-116, and MCF-7 with IC50 = 4.13 +/- 0.2, 6.93 +/- 0.3, and 8.67 +/- 0.5 mu M, respectively. Compounds 5(c), 5(f), 6(b), 5(d), and 6(c) showed the highest anticancer activities against HepG2 cells with IC50 of 5.93 +/- 0.2, 6.58 +/- 0.4, 8.10 +/- 0.7, 8.75 +/- 0.7, and 9.95 +/- 0.9 mu M, respectively; HCT-116 cells with IC50 of 7.14 +/- 0.4, 9.10 +/- 0.8, 7.91 +/- 0.6, 9.52 +/- 0.5, and 12.48 +/- 1.1 mu M, respectively; and MCF-7 cells with IC50 of 8.93 +/- 0.6, 10.11 +/- 0.9, 12.31 +/- 1.0, 9.95 +/- 0.8, and 15.70 +/- 1.4 mu M, respectively, compared with sorafenib as a reference drug with IC50 of 9.18 +/- 0.6, 5.47 +/- 0.3, and 7.26 +/- 0.3 mu M, respectively. The most active compounds 5(c-f) and 6(b,c) were further evaluated for their vascular endothelial growth factor receptor-2 (VEGFR-2) inhibition. Compounds 5(e) and 5(c) potently inhibited VEGFR-2 at lower IC50 values of 0.07 +/- 0.01 and 0.08 +/- 0.01 mu M, respectively, compared with sorafenib (IC50 = 0.1 +/- 0.02 mu M). Compound 5(f) potently inhibited VEGFR-2 at low IC50 value (0.10 +/- 0.02 mu M) equipotent to sorafenib. Our design was based on the essential pharmacophoric features of the VEGFR-2 inhibitor sorafenib. Molecular docking was performed for all compounds to assess their binding pattern and affinity toward the VEGFR-2 active site.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem