In an article, author is Wu, Zhuo, once mentioned the application of 2377-81-3, Name: Tetrafluoroisophthalonitrile, Name is Tetrafluoroisophthalonitrile, molecular formula is C8F4N2, molecular weight is 200.0926, MDL number is MFCD00013290, category is benzoxazole. Now introduce a scientific discovery about this category.
A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT(1) receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem