128156-54-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-4-carboxylate, cas is 128156-54-7,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 8-chloro-3-(1-methyl-1H-pyrazol-4-yl)isoquinoline (IntermediateD,310 mg,1.27mmol),methyl benzo[d]oxazole-4-carboxylate (150 mg,0.85 mmol)and K3P04(539 mg,2.54 mmol)in NMP (8 mL)were added bis(1-adamantyl)-butyl-phosphane (61 mg,10 0.17 mmol)palladium(II)acetate (19 mg,0.08 mmol). The reaction mixture was stirred at roomtemperature for 15 min and heated to 125 oc for 24 h under a nitrogen atmosphere. Aftercooling the reaction to room temperature,the mixture was filtered and concentrated in vacuo.The crude residue was purified by silica gel column chromatography (petroleum ether/EtOAc =3:1)to give the title compound (150 mg,46%)as a brown solid. LCMS M/Z (M+H)385.
The chemical industry reduces the impact on the environment during synthesis,128156-54-7,Methyl benzo[d]oxazole-4-carboxylate,I believe this compound will play a more active role in future production and life.
Reference：
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
Benzoxazole – Wikipedia
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