New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals. In an article, author is Lu, Ju-You, once mentioned the application of 367-11-3, Name: 1,2-Difluorobenzene, Name is 1,2-Difluorobenzene, molecular formula is C6H4F2, molecular weight is 114.09, MDL number is MFCD00000284, category is benzoxazole. Now introduce a scientific discovery about this category.
A copper-catalyzed C-N/C-O coupling has been developed for synthesis of 2-aminoarylbenzoxazole derivatives. The protocol uses readily available 2-halo-N-(2-halophenyl)benzamides and amines as the starting materials, and the corresponding 2-aminoarylbenzoxazoles were obtained in good to excellent yields. Both aromatic and aliphatic amines were tolerated, and no ligand was used in this reaction. Gram-scale synthesis was also carried out successfully. These results showed the potential synthetic value of this new reaction in organic synthesis. (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem