New discoveries in chemical research and development in 2021. As an important bridge between the micro, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Gonnard, Laurine, once mentioned the application of 504-02-9, Recommanded Product: 504-02-9, category is benzoxazole. Now introduce a scientific discovery about this category.
alpha-Substituted amines are present in a myriad of biologically active natural and synthetic products. With the objective of developing atom-economical reactions, a panel of synthetic methods allowing the direct functionalization of C(sp(3))-H bonds adjacent to the nitrogen atom have been developed. The field remains dominated by the sequence a-lithiation/addition on an electrophile even if the use of reactive organolithium reagents is not compatible with all functional groups. Over the past ten years, an increasing interest has been devoted to metal-catalyzed C-H-activation, some studies being specially dedicated to C(sp(3))-H bond activation. Notably, this approach has been envisioned to perform direct alpha-functionalization of amines. The aim of this article is to give an overview of synthetic methods for transition metal-catalyzed alpha-allcylation of amines by C(sp(3))-H bond activation. (C) 2018 Published by Elsevier Ltd.
Interested yet? Keep reading other articles of 504-02-9, you can contact me at any time and look forward to more communication. Recommanded Product: 504-02-9.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem