New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals. In an article, author is Pino-Cuevas, Arantxa, once mentioned the application of 92-86-4, HPLC of Formula: https://www.ambeed.com/products/92-86-4.html, Name is 4,4′-Dibromobiphenyl, molecular formula is C12H8Br2, molecular weight is 311.9999, MDL number is MFCD00000101, category is benzoxazole. Now introduce a scientific discovery about this category.
Aim: Obtain radioimages of amyloid-beta fibers using Tc-99m-complexes. Methodology: Tridentate thiosemicarbazone and thiocarbonohydrazone ligands containing fragments (stilbene, azobenzene, benzothiazole or benzoxazole) with affinity for amyloid-beta fibers and its Re(I) complexes have been prepared. The molecular structures of several ligands and complexes were determined by x-ray diffraction. Binding affinity studies toward A beta 1- 42 fibers were performed for the ligands and Re(I) complexes. The ability of formation of some Tc-99m(I) complexes, their biodistribution and in vivo stability have been established. Results & conclusion: Complexes of stilbene and benzothiazole thiosemicarbazonates show similar affinity for amyloid-beta fibers to the free ligand. These Tc-99m complexes present a reasonable in vivo stability and a low capability to cross the blood-brain barrier although not sufficient to brain amyloid imaging.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem