New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals. In an article, author is Garrido, Amanda, once mentioned the application of 2892-51-5, COA of Formula: https://www.ambeed.com/products/2892-51-5.html, Name is 3,4-Dihydroxy-3-cyclobutene-1,2-dione, molecular formula is C4H2O4, molecular weight is 114.06, MDL number is MFCD00001334, category is benzoxazole. Now introduce a scientific discovery about this category.
Benzoxazole and benzimidazole are commonly encountered heterocycles in medicinal chemistry and their functionalisation around 1-, 2-, 5-, and/or 6-positions provides a wide range of molecules of biological interest. In this manuscript, a straightforward preparation of diversely and highly substituted benzimidazoles and benzoxazoles on these positions, from a common starting material, a 3,3-dibromoacrolein, is described. Such acrolein derivatives are almost never described in the literature or used as ‘building-block’ for organic synthesis. The double electrophilicity of this substrate was found to be advantageous for condensation with two equivalents of various 1,2-diaminobenzene or 2-aminophenol derivatives. This one-pot reaction performed under metal-free and mild conditions allows the creation of three new carbon-heteroatom bonds and affords the desired heterocycles.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem