New discoveries in chemical research and development in 2021. As an important bridge between the micro, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Wu, Dan, once mentioned the application of 348-54-9, Quality Control of 2-Fluoroaniline, category is benzoxazole. Now introduce a scientific discovery about this category.
An NFSI/KF-mediated scission/recombination of C-C double bonds for [4+1] annulation is reported, leading to the efficient synthesis of a wide range of fully substituted oxazoles in good to excellent yields under mild redox-neutral conditions. This methodology might open a new entry for the preparation of structurally applicable heterocyclic systems in a highly functional-group-compatible manner.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem