New research progress on 405-50-5 in 2021.Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 405-50-5, Name is 2-(4-Fluorophenyl)acetic acid, molecular formula is , belongs to benzoxazole compound. In a document, author is Wang, Junfeng, Safety of 2-(4-Fluorophenyl)acetic acid.
Unassymetric bis[2-(2′-hydroxyphenylbenzoxole)] bis(HBO) derivatives with a DPA functionality for zinc binding have been developed with an efficient synthetic route, using the retrosynthetic analysis. Comparison of bis(HBO) derivatives with different substitution patterns allows us to verify and optimize their unique fluorescence properties. Upon binding zinc cation, bis(HBO) derivatives give a large fluorescence turn-on in both visible (lambda(em) approximate to 536 nm) and near-infrared (NIR) window (lambda(em) approximate to 746 nm). The probes are readily excitable by a 488 nm laser, making this series of compounds a suitable imaging tool for in vitro and in vivo study on a confocal microscope. The application of zinc binding-induced fluorescence turn-on is successfully demonstrated in cellular environments and thrombus imaging.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem