New discoveries in chemical research and development in 2021. As an important bridge between the micro, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Song, Yan, once mentioned the application of 352-34-1, Synthetic Route of 352-34-1, category is benzoxazole. Now introduce a scientific discovery about this category.
A fluorescent probe to detect biothiols (GSH/Hcy/Cys) was synthesized with benzothiazole as the fluorophore and nitromethane as the recognition group. The recognition mechanism of the fluorescent probe was deduced. It was found that a nitroalkene in the molecule was used as the recognition site for this probe and reacted with the mercapto group of the biothiols by electrophilic addition, significantly enhancing the fluorescent signal. Experimental results showed that the fluorescent probe had a low detection limit, good selectivity, strong anti-interference ability, and good naked eye recognition. The probe could detect biothiols (GSH/Hcy/Cys) in 20% organic solvent, with detection limits of 0.33 mu M, 0.70 mu M, and 0.87 mu M, respectively. The probe will be applied further in biosensors and other fields.
Synthetic Route of 352-34-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 352-34-1.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem