An article Synthesis and Microbiological Properties of Novel Bis-Quaternary Ammonium Compounds Based on Biphenyl Spacer WOS:000475679400004 published article about ANTIMICROBIAL AGENTS; SERIES in [Vereshchagin, Anatoly N.; Gordeeva, Alexandra M.; Frolov, Nikita A.; Proshin, Pavel I.; Egorov, Mikhail P.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Procpekt, Moscow 119991, Russia; [Gordeeva, Alexandra M.; Proshin, Pavel I.] DI Mendeleev Univ Chem Technol Russia, Higher Chem Coll, Russian Acad Sci, Miusskaya Sq 9, Moscow 125047, Russia; [Hansford, Karl A.] Univ Queensland, Hansford Inst Mol Biosci, Brisbane, Qld 4072, Australia in 2019, Cited 30. SDS of cas: 92-86-4. The Name is 4,4′-Dibromobiphenyl. Through research, I have a further understanding and discovery of 92-86-4
Novel gemini (tail-head-spacer-head-tail) bis-quaternary ammonium compounds (bis-QACs) with a biphenyl spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride (BAC) and chlorhexidine digluconate (CHG). The series of compounds showed high inhibitory activity against five bacterial strains and two fungi. The compounds, which contain C8H17-C10H21 aliphatic tails best within the series. A counterion change does not affect MIC in general. Cytotoxicity on human embryonic kidney cells and haemolysis were also investigated. For bis-QACs cytotoxic effect was lower than for 3,3 ‘-[1,4-phenylenebis(oxy)]bis(1-dodecylpyridinium) dibromide (3PHBO-12), that is their closest structural analogue, and for BAC.
SDS of cas: 92-86-4. Welcome to talk about 92-86-4, If you have any questions, you can contact Vereshchagin, AN; Gordeeva, AM; Frolov, NA; Proshin, PI; Hansford, KA; Egorov, MP or send Email.
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