The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ) is researched.Synthetic Route of C8H8N2S.Sorba, Giovanni; Garrone, Adele; Serafino, Anna; Gasco, Alberto; Orsetti, Marco published the article 《Potential histamine H2-receptor antagonists: ranitidine analogs containing 2-amino-5(6)-substituted benzimidazole moieties. (1)》 about this compound( cas:27231-36-3 ) in European Journal of Medicinal Chemistry. Keywords: ranitidine analog preparation antihistaminic; aminobenzimidazole preparation antihistaminic; structure antihistaminic activity aminobenzimidazole. Let’s learn more about this compound (cas:27231-36-3).
A series of ranitidine analogs (I: R = H, Me, OMe, Cl, CONH2, CN, and NO2) were synthesized and tested for its in vitro H2-antagonism by using the histamine induced guinea pig atria chronotropic response. These substances generally display good H2-antagonist activity. Some considerations of the structure relationships are also discussed, in particular the physicochem. properties of the benzimidazole moiety.
There is still a lot of research devoted to this compound(SMILES：SC1=NC2=CC(C)=CC=C2N1)Synthetic Route of C8H8N2S, and with the development of science, more effects of this compound(27231-36-3) can be discovered.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem