Liu, Kang Chien; Chang, Jo Lan; Chen, Chieh Fu published the article 《Guanidine-annelated heterocycles. II. Synthesis and antihypertensive activity of some 9H-1,2,4-triazolo[4,3-a]benzimidazoles》. Keywords: triazolobenzimidazole preparation antihypertensive; benzimidazole hydrazino cyclization orthoacetate; orthoacetate cyclization hydrazinobenzimidazole.They researched the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ).Safety of 2-Mercapto-5-methylbenzimidazole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27231-36-3) here.
The benzimidazoles I (R = SH; R1 = R2 = H, Me; R = H, R1 = Me), prepared from 3,4-R1R2C6H2(NH2)2-1,2 and CS2, were methylated followed by treatment with H2NNH2 to give I (R = NHNH2), which were cyclized with HCO2H or MeC(OEt)3 to give the triazolobenzimidazoles II (R1 = R2 = R3 = H; R1 = R2 = H, Me, R1 = H, R2 = Me, R3 = Me). At 60 mg/kg I (R1 = R2 = R3 = H) reduced the blood pressure in rats by 25.4 ± 8.5 mm after 30 min.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem