So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ling, Johanne; Mara, David; Roure, Baptiste; Laugeois, Maxime; Vitale, Maxime R. researched the compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole( cas:503538-69-0 ).Formula: C38H24F4O4P2.They published the article 《Copper(I)-Catalyzed Dearomative (3 + 2) Cycloaddition of 3-Nitroindoles with Propargylic Nucleophiles: An Access to Cyclopenta[b]indolines》 about this compound( cas:503538-69-0 ) in Journal of Organic Chemistry. Keywords: cyclopentaindoline preparation diastereoselective; nitroindole propargylic nucleophile dearomative cycloaddition copper catalyst. We’ll tell you more about this compound (cas:503538-69-0).
The copper(I)-catalyzed dearomatization of 3-nitroindoles I [R1 = 4-Me, 5-Cl, 7-CO2Me, etc.; R2 = Ac, Bz, (4-methylphenyl)sulfonyl, etc.] and 3-nitro-1-benzofuran-5-yl acetate with propargylic nucleophiles CHCCH2R3 (R3 = 1,3-dimethoxy-1,3-dioxopropan-2-yl, 1,3-bis(benzyloxy)-1,3-dioxopropan-2-yl, 4-methylbenzene-1-sulfonamidyl, etc.) is described. In mild reaction conditions, this original dearomative (3+2) cycloaddition process gives access to a wide variety of cyclopenta[b]indolines e.g., II in good to excellent yields, with high functional group tolerance. The proof of concept that an enantioselective version of this reaction is accessible by employing chiral phosphorus ligands was obtained. A mechanism proposal is given based on kinetic studies.
As far as I know, this compound(503538-69-0)Formula: C38H24F4O4P2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem