Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 503538-69-0, is researched, SMILESS is FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1, Molecular C38H24F4O4P2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Access to enantioenriched α-amino esters via rhodium-catalyzed 1,4-addition/enantioselective protonation, Author is Navarre, Laure; Martinez, Remi; Genet, Jean-Pierre; Darses, Sylvain, the main research direction is amino acid ester asym preparation; aryltrifluoroborate amino acrylate conjugate addition protonation rhodium.Recommanded Product: 503538-69-0.
Conjugate addition of potassium trifluoro(organo)borates to dehydroalanine derivatives, mediated by a chiral rhodium catalyst and in situ enantioselective protonation, afforded straightforward access to a variety of protected α-amino esters with high yields and enantiomeric excesses up to 95%. Among the tested chiral ligands and proton sources, Binap, in combination with guaiacol (2-methoxyphenol), an inexpensive and nontoxic phenol, afforded the highest asym. inductions. Organostannanes have also shown to participate in this reaction. By a fine-tuning of the ester moiety, and using Difluorophos as chiral ligand, increased levels of enantioselectivity, generally close to 95%, were achieved. Deuterium labeling experiments revealed, and DFT calculation supported, an unusual mechanism involving a hydride transfer from the amido substituent to the α carbon explaining the high levels of enantioselectivity attained in controlling this α chiral center.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem