So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Efange, Simon M. N.; Kamath, Ashok P.; Khare, Anil B.; Kung, Mei-Ping; Mach, Robert H.; Parsons, Stanley M. researched the compound: 2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride( cas:96651-85-3 ).Application of 96651-85-3.They published the article 《N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4′-piperidine]: Vesamicol Analogs with Affinity for Monoamine Transporters》 about this compound( cas:96651-85-3 ) in Journal of Medicinal Chemistry. Keywords: monoamine transporter phenyltropane derivative preparation structure; methylspiro indolinepiperidine preparation monoamine transporter structure. We’ll tell you more about this compound (cas:96651-85-3).
As part of our ongoing structure-activity studies of the vesicular acetylcholine transporter ligand 2-(4-phenylpiperidino)cyclohexanol (vesamicol), N-hydroxy(phenyl)alkyl derivatives of 3β-phenyltropane, and 1-methylspiro[1H-indoline-3,4′-piperidine] were synthesized and tested for binding in vitro. Although a few compounds displayed moderately high affinity for the vesicular acetylcholine transporter, no compound was more potent than the prototypical vesicular acetylcholine transporter ligand vesamicol. However, a few compounds displayed higher affinity for the dopamine transporter than cocaine. We conclude that modification of the piperidyl fragment of vesamicol will not lead to more potent vesicular acetylcholine transporter ligands.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem