So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhong, Feng; Xue, Qi-Yan; Yin, Liang researched the compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole( cas:503538-69-0 ).Electric Literature of C38H24F4O4P2.They published the article 《Construction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction》 about this compound( cas:503538-69-0 ) in Angewandte Chemie, International Edition. Keywords: chiral allenol preparation copper catalyst asym alkynylogous aldol; aldol reaction; alkynylogous reaction; allenes; asymmetric catalysis; copper. We’ll tell you more about this compound (cas:503538-69-0).
Chiral 2,3-allenols were constructed through copper(I)-catalyzed asym. direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the alkynylogous aldol reaction with (R)-DTBM-SEGPHOS as the ligand proceeded smoothly to furnish the products in excellent regioselectivity with good to high diastereoselectivity and excellent enantioselectivity. In the cases of aliphatic aldehydes, esters of but-2-yn-1-ol as the substrates and (R,R)-Ph-BPE as the ligand are crucial to get good to high regio- and diastereoselectivity. The produced chiral 2,3-allenols are easily transformed into synthetically useful 2-furanones through cyclization. Finally, the developed method was successfully applied in the rapid synthesis of two chiral intermediates toward the synthesis of two pharmaceutically active compounds that are proposed for the treatment of neurol. disorders.
In some applications, this compound(503538-69-0)Electric Literature of C38H24F4O4P2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem