Zhang, Meng-Cheng; Wang, Dong-Chao; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming; You, Shu-Li published an article about the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3,SMILESS:CCC1=NC2=CC=CC=C2O1 ).COA of Formula: C9H9NO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:6797-13-3) through the article.
Herein, the development of enantioselective dearomative [3+2] cycloaddition reactions of benzazoles with aminocyclopropanes via kinetic resolution has been reported. In the presence of a copper complex, derived from Cu(OTf)2 and bisoxazoline, a series of hydropyrrolo-benzazole derivatives containing quaternary stereogenic centers were obtained in high yields (up to 99%) with excellent enantioselectivity (up to 99% enantiomeric excess [ee]). With the same catalytic system, 2-amino cyclopropane-1,1-dicarboxylates with a high enantiomeric purity (up to 98% ee) were also obtained by an efficient kinetic resolution (s values of up to 95). In addition, the utility of this method was showcased by the facile transformation of products into several important heterocyclic frameworks, including pyrrolo-benzothiazine and 1,5-benzothiazepine.
《Cu-catalyzed Asymmetric Dearomative [3+2] Cycloaddition Reaction of Benzazoles with Aminocyclopropanes》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Ethylbenzo[d]oxazole)COA of Formula: C9H9NO.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem