On January 20, 2016, Lee, Ha-Rim; Farhanullah; Lee, JiSoo; Jajoo, Rahul; Kong, Sun-Young; Shin, Jae-Yeon; Kim, Jae-Ouk; Lee, Jiyoun; Lee, Jeewoo; Kim, Hyun-Jung published an article.Recommanded Product: 1268137-13-8 The title of the article was Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells. And the article contained the following:
Identification of small mols. that direct neural stem cells (NSCs) into specific cell types would be helpful to understand the mol. mechanisms involved in regulation of NSC fate, and facilitate the development of therapeutic applications. In the current study, we developed and screened small mols. that can modulate the fate of NSCs that are derived from rat fetal cortex. Among these compounds, compounds 5 and 6 successfully differentiated NSCs into astrocytes and neurons, resp. Compound 5 induced astrocytogenesis by increasing expression of interleukin-6, bone morphogenetic protein 2 and leukemia inhibitory factor and through consequent phosphorylation of signal transducer and activator of transcription 3 and Sma- and Mad-related protein 1/5/8 in NSCs. In addition, compound 5 increased the expression of fibroblast growth factor (FGF) 2 and FGF8 which may regulate the branching and morphol. of astrocytes. Taken together, our results suggest that these small mols. can serve as a useful tool to study cell fate determination in NSCs and be used as an inexpensive alternative to cytokines to study mechanisms of astrocytogenesis. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Recommanded Product: 1268137-13-8
The Article related to benzothiazole derivative preparation structure activity astrocytogenesis stat3 smad erk, astrocytogenesis, differentiation, neural stem cells, neurodegeneration, neurological agents, structure−activity relationships and other aspects.Recommanded Product: 1268137-13-8
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem