1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
Evidence obtained previously from in vivo experiments indicated that there are some possible relations between the diuretic actions and the physiol. dispositions of several sulfonamide diuretics. In the present investigation, tubular transport of these compounds was studied in slices of the rat kidney by a modification of the method developed by Cross and Taggart for PAH (p-aminohippuric acid) (CA 44, 6037h). Chem. determinations of these compounds were carried out by a modification of Baer, et al. (loc. cit) and S/M ratios (ratios of concentrations of drug in slice vs. medium after incubating at 25¡ã for 2 hrs.) were calculated Both HCT (hydrochlorothiazide) and PAH accumulated to a considerable degree in the renal slices. The S/M ratios of these compounds were 9.3 and 7.2, resp. However, when the incubation was carried out at 37¡ã, the S/M ratios of both drugs decreased appreciably in spite of an increase of QO2. Variations from an optimal pH of 7.8 to 8.0 towards either the acid or alk. side produced a decrease of S/M values for both drugs. Anaerobic conditions inhibited, while addition of acetate stimulated, the accumulation of HCT in the slices. Dinitrophenol (2.5 ¡Á 10-5M) or cyanide (50-100 ¡Á 10-5M) decreased the S/M values of PAH, CT (chlorothiazide), and HCT considerably. Diodrast or penicillin G, when added in concentrations 15 times as high as that of the substrate, also decreased the S/M value of HCT, without affecting the QO2 of the slices. These results suggest that HCT and its analogs may share a common renal transport mechanism with PAH, penicillin G, and Diodrast. In addition, the S/M values of 8 sulfonamide diuretics (including CT and HCT) were compared. It was found that those compounds such as HCT-55 (5-chlorohydrochlorothiazide), HCT, and HFT (hydroflumethiazide) which showed relatively high diuretic activities also exhibited higher S/M values. On the contrary, inactive compounds or compounds with low diuretic activities, such as HCT-18 (3-[3,4-dimethoxy-2-ethoxycarbonylphenyl]hydrochlorothiazide), CT, and DSA (5-chloro-2,4-disulfamylaniline) had lower S/M values. These results would be in favor of the concept that these sulfonamide derivatives exert their diuretic actions in the process of being transported by the renal tubular epithelium. CT-S (benzthiazide) accumulated in the liver slices of the rat to the same extent as in the renal slices, while HCT accumulated preferentially in the kidney slices.
Oral diuretics. IV. The uptake of some sulfonamide diuretics by rat renal slices. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem