1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
Chlorothiazide, 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,l-dioxide, yields a 3,4-dihydro derivative, hypothiazide (I). Taking the diuretic and saluretic activities (in rats) of chlorothiazide as 1, resp. activities of I were 4.1, 10.8; among derivatives, peak activity (16.0, 40.0) was reached with pentamethylene instead of the 2 H atoms in the 3-position. Other activating substitutions were 5-Cl (5.8, 4.0); 3-Me (1.7, 4.0); 3-CCl3 (1.1, 6.2); and ring rupture at 2 to form 1-SO2NH2 and NHCH2OMe groups (3.5, 7.5). Other substitutions, giving activities less than 1, were 6-NH2, 3-H (no activity), 5-Br. After ring rupture the groups SO2NHMe (0.7, 0.9) and SO2NEt2 (0,0) lowered activity. Effective diuretic doses (mg./kg.) were determined for I derivatives in which the 3-CH2 group is replaced: CHEt 0.5; CHCH:CH2 0.2; CHCH:CHMe 1.0; and side rings, 4-methylcyclohexyl 4.0; cyclopentyl 0.2; thiacyclohexyl 0.2; dithiacyclopentyl 0.1; piperidyl 4.0; N-ethylpiperidyl 4.0; I 0.2. The relatively inactive N-ethylpiperidyl derivative had a pronounced hypotensive effect.
Diuretic effects of dihydrochlorothiazide derivatives. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem