1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
As compared with chlorothiazide, the effect of hydrochlorothiazide (I) was 10-fold stronger. Its effect could be increased further by introducing a dichloromethyl group at C-3, or by building a 3rd ring into the compound at this point. The resulting 3,3-pentamethylene-I and 3,3-(3-thiapenta-methylene)-I were 2-4-fold more effective than I. The I derivatives increased Na excretion. As long as a Na excess was present in the organism, the K excretion was not affected. Extirpation of the adrenals did not alter the effect of I if the rats were kept on a physiol. sufficient cortexone and hydrocortisone regimen. Excess cortexone doses >1.5 mg./kg. or >0.1 mg. aldosterone/kg. inhibited the I effect.
Diuretic effect of hydrochlorothiazide derivatives. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem