1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Treatment of NH-sulfoximines with pseudocyclic benziodoxole triflate results in N-I bond formation leading to a new type of sulfoximidoyl-containing hypervalent iodine(III) reagents in high yields. Degradation studies revealed a pronounced stability in both the solid state and in solution
Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents: 1-Sulfoximidoyl-1,2-benziodoxoles. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem