1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Free NH-sulfoximines were directly prepared from sulfoxides through iron catalysis by applying a readily available, shelf-stable hydroxylamine triflic acid salt. No addnl. oxidant is needed, and the substrate scope is broad, including a range of heterocyclic compounds Thus, e.g., imidation of PhS(:O)Me with O-(4-nitrobenzoyl)hydroxylamine.HOTF in presence of FeSO4 and 1,10-phenanthroline afforded PhS(:O)(:NH)Me (98%, 93% isolated).
Iron(II)-Catalyzed Direct Synthesis of NH Sulfoximines from Sulfoxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem