1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
A novel and efficient method was developed for the synthesis of N-sulfenyl sulfoximines I [R = Ph, Bn, 2-pyridyl, etc.; R1 = Me, Ph, 3-pyridyl, etc.; R2 = Me, 4-ClC6H4, 2-naphthyl, etc.; R1R2 = (CH2)4] via cross-coupling reaction of sulfoximines and N-thiosuccinimides using hexagonal boron nitride-supported copper-¦Ã-cyclodextrin nanocatalyst. This heterogeneous catalyst afforded the desired products with wide scope of substrates, good to excellent yields and low-toxicity solvent. Moreover, after being reused ten times, there was almost no significant loss of its catalytic activity.
h-BN@Copper(II) nanomaterial catalyzed cross-coupling reactions between sulfoximines and N-(phenylthio)-succinimide under mild condition. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem