1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
cf. ibid. 25,229(1962). On the basis of testing 15 sulfonamide derivatives for diuretic action in rats, 6 compounds [4 highly active: hydrochlorothiazide(HCT), 5-chlorohydrochlorothiazide(HCT-55), benzthiazide(CT-S), and 3-diethylaminomethylhydrochlorothiazide(HCT-16); one moderately active: chlorothiazide(CT); and one inactive: 3-(3,4-dimethoxy-2-ethoxycarbonylphenyl)hydrochlorothiazide(HCT-18)] were chosen for comparative study on physiol. disposition in rats. A modification of the method of Baer, et al. (CA 53, 11639f) was used for the determination of these compounds in biol. materials. After an oral dose of 20 mg./kg., the rate of disappearance of the various compounds from the gastrointestinal tract was found to follow the decreasing order of HCT-55, CT-S, HCT-16, HCT, CT, and HCT-18. This order roughly parallels their oil-water partition coefficients with the exception of HCT-18, which was found to have the highest partition coefficient, although absorbed rather slowly. CT was demonstrated to have the lowest partition coefficient, which may explain its relatively slow rate of absorption from gastrointestinal epithelium. In addition, its low pKa value (the pKa1 of CT was found to be 6.7, while those of all other compounds investigated were between 9.0-9.2) may also affect its rate of absorption. For all compounds given orally, the highest concentrations were found in the kidneys, though three patterns of tissue distribution were observed. CT, HCT, and HCT-55 were all characterized by a specific affinity for the kidney tissue and very low levels in other organs; DSA was distributed rather nonspecifically in various tissues; while for CT-S and HCT-16, equally high levels were found both in the kidneys and in the liver. When given orally, the rate of excretion of the compounds in the urine was found to be essentially parallel to the rapidity of disappearance from the gastrointestinal tract, i.e., HCT-55 > CT-S > HCT > HCT-16 > CT. After intravenous injection, nearly all of the administered dose of CT-S and HCT was found in the first five-hr. urine. The percentages of urinary excretion of HCT-55, HCT-16, CT, DSA, and HCT-18 were 92, 84, 79, 58, and 29%, resp. The possible relation between the characteristics of the renal transport of these compounds and their diuretic potencies are discussed in some detail.
Oral diuretics. III. Characteristics of the dispositions of some sulfonamide diuretics and their relations to diuretic actions. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem