1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
The synthesis of tricyclic dibenzothiazines I (R = 4-FC6H4, 4-H3COC6H4, biphenyl-4-yl, etc.; R1 = H, Me, Br, NO2; R2 = Me, Et) by a ruthenium-catalyzed ortho arylation of Ph sulfoximines with aromatic boronic acids followed by intramol. cyclization in the presence of a palladium catalyst in two consecutive steps were described. Chiral dibenzothiazines II and III were prepared efficiently by using chiral Ph sulfoximine in a similar protocol.
Ruthenium- and palladium-catalyzed consecutive coupling and cyclization of aromatic sulfoximines with phenylboronic acids: an efficient route to dibenzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem