1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Herein, rhodium-catalyzed oxidative C-H/C-H cross-coupling of S-aryl sulfoximines with thiophenes/benzothiophenes via a chelation-assisted strategy provided an efficient approach for the construction of (S-methylsulfonimidoyl)phenyl-substituted thiophenes and benzothiophenes, e.g., I. Selected products were further converted to [1]benzothieno[3,2-b][1]benzothiophenes II [R1 = F, Cl, Br, Ph]. The protocol also exhibited a good compatibility with halogen substituents, and thus paved the way for further transformation to benzothiazines III [R2 = H, t-Bu]. Compounds III showed a deep blue emission with Commission Internationale de ‘Eclairage (CIE) coordinates of (0.15, 0.04), a high quantum yield and a delayed fluorescence lifetime.
Rh(III)-catalysed C-H/C-H cross-coupling of S-aryl sulfoximines with thiophenes: facile access to [1]benzothieno[3,2-b][1]benzothiophene (BTBT) and benzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem