1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
The following compounds were studied in adult rats: chlorothiazide (K30), 6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide (K32), 6-chloro-7-sulfamoyl-3,4-dihydro-3-trichloromethyl-1,2,4-benzothiadiazine 1,1-dioxide (K33), 6-chloro-7-sulfamoyl-3,4-dihydro-3- methyl-1,2,4-benzothiadiazine 1,1-dioxide (K34), 6-amino-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide (K35), benzo-1,2,4,9,8,6-dithiadiazine 1,1,9,9-tetroxide (K36), 7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide (K37), 5,6-dichloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide (K38), and 7-sulfamoyl-3-trichloromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide (K39). K37 and K38 with only a H at C-6 had a weak diuretic action at a dose of 4 mg./kg. A dose of 2 mg. of K30/kg. produced a larger output of Cl than 4 mg./kg. K36 was ineffective over the dose range of 0.54 mg./kg. Cl excretion showed a marked decline with K36. The dihydrochlorothiazide compounds proved to be more potent than K30. With respect to their effect on water diuresis, the order of potency was as follows: K38 > K32 > K34 > K33 > K30; for Cl excretion it was K32 > K34 > K38 > K33 > K30. K38 was most effective for water diuresis while K32 and K34 would be the compounds of choice for increasing the Cl output. The activity of some of these compounds was compared with that of urea. Albuminuria, feebleness, and anorexia were observed in animals given 2-3 g. of K30/kg. All of the test animals survived.
The diuretic action of dihydrochlorothiazide derivatives. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem