1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Upon treatment with Cs2CO3, S-methyl-N-ynonylsulfoximines R1S(O)(CH3)=NC(O)CCR2 (R1 = Ph, pyridin-2-yl, 3-fluorophenyl, etc.; R2 = Ph, 4-cyanophenyl, 2-fluorophenyl, etc.) undergo 5-exo-dig cyclizations to give three-dimensional heterocycles (Z)-I. The reactions proceed at ambient temperature with a wide range of substrates affording the corresponding products (Z)-I in good to excellent yields.
Three-Dimensional Heterocycles by 5-exo-dig Cyclizations of S-Methyl-N-ynonylsulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem