(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.
A photochem. approach for the preparation of ¦Á-keto-N-acyl sulfoximines ArC(O)C(O)N=S(R)(R1)=O (Ar = 2-naphthyl, 3-chlorophenyl, 4-bromophenyl, etc.; R = Me, Et, t-Bu, Bn; R1 = Me, Ph, 2-chlorophenyl, etc.) from NH sulfoximines NH=S(R)(R1)=O and gem-difluoroalkenes ArCH=CF2 has been developed. In the presence of NBS, the reactions proceed in air without the need of a photocatalyst or addnl. oxidant. Results of mechanistic studies suggest that the two oxygens in the products stem from water and dioxygen.
Visible-Light-Mediated ¦Á-Ketoacylations of NH-Sulfoximines with gem-Difluoroalkenes. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem