(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.
A novel and efficient synthetic method to construct isoquinolone e.g., I scaffold via the Rh(III)-catalyzed (4 + 2) annulation of benzamide RC(O)NHOMe (R = Ph, naphthalen-2-yl, 2-OMeC6H4) with an unreported coupling reagent Me 2-chloroacrylate was reported. Accordingly, other valuable 1,2-benzothiazine II (R1 = Me, Et, Ph; R2 = OMe, H, F, etc.; R3 = OMe, H, Cl; R4 = Cl, H, Br) and naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine e.g., III derivatives are also obtained through a similar synthetic protocol. Thus, the developed method is highlighted by high yield and reaction versatility.
Synthesis of Isoquinolone, 1,2-Benzothiazine, and Naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine Derivatives via Rhodium(III)-Catalyzed (4 + 2) Annulation. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem