Cyclopalladated ferrocenylimine catalyzed ortho-arylation of sp2 C-H bond substrates containing the directing group was written by Li, Ya-Nan;Yang, Fan;Wu, Yang-Jie. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2008.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:
A novel and efficient catalytic system for ortho-arylation of sp2 C-H bond substrates containing the directing group using cyclopalladated ferrocenylimine as catalyst was developed. The arylation showed high regioselectivity and only occurred on the less sterically hindered ortho-C-H bond. The reaction could be compatible to diverse functional groups such as CH3, CH3O, and CH3CO, as well as Br and Cl substituents, which would permit to be functionalized further to construct new compounds with more complicated structures. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem