Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes was written by Aksenov, Alexander V.;Smirnov, Alexander N.;Aksenov, Nicolai A.;Bijieva, Asiyat S.;Aksenova, Inna V.;Rubin, Michael. And the article was included in Organic & Biomolecular Chemistry in 2015.Computed Properties of C9H9NO This article mentions the following:
PPA-induced umpolung triggers efficient nucleophilic addition of unactivated anilines to nitroalkanes to produce N-hydroxyimidamides. The latter undergo sequential acid-promoted cyclocondensation with ortho-hydroxy or ortho-amino moieties to afford benzoxazoles and benzimidazoles, e.g., I, resp. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Computed Properties of C9H9NO).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Computed Properties of C9H9NO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem