A cationic iridium-catalyzed C(sp3)-H silylation of 2-Alkyl-1,3-azoles at the α-position in the 2-alkyl group leading to 2-(1-Silylalkyl)-1,3-azoles was written by Hirano, Masaya;Fukumoto, Yoshiya;Matsubara, Nao;Chatani, Naoto. And the article was included in Chemistry Letters in 2018.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:
The regioselective silylation of the α-C(sp3)-H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOPtBu)IrHCl and NaBArF4, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is required for the reaction to proceed. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Safety of 2,5-Dimethylbenzoxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem