Transfer of the substituent effect in series of cis- and transcinnamic acids was written by Zdanovich, V. I.;Parnes, Z. N.;Kursanov, D. N.. And the article was included in Doklady Akademii Nauk SSSR in 1965.Related Products of 5676-58-4 This article mentions the following:
Potentiometric determination of dissociation constants was performed for the cis- and trans-cinnamic acids and their benzoic acid analogs in 49% EtOH at 25°. The following K × 106 were found for: benzoic acids, trans-cinnamic acid and cis-cinnamic acids, resp. with indicated substituents: H 1.25; 1.05 (m. 135.2-5.7°); 2.79 (m. 67-8°); p-O2N 12.0; –; –; m-O2N 13.7; 3.82 (m. 205-6°); 6.40 (m. 159-9.5°); p-Cl 2.38; 2.00 (m. 249.5-9.8°); 4.09 (m. 112.8-14°); p-Br 3.65; 1.92 (m. 264.7-5.5°); 4.02 (m. 127.6-8.5°); p-MeO 0.68; 0.70 (m. 188-8.2°); 1.78 (m. 68.8-9.7°); p-H2N 0.17; –; –; p-Me2N –; 0.32 (m. 118-20°); –. The following Hammett reaction constants were determined: ester hydrolysis trans isomer 0.540; cis isomers 0.461; dissociation of the acids trans isomers 0.539; cis isomers 0.422. Transfer of the substituent effects is more effective in trans-cinnamic acids than in the cis isomers. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Related Products of 5676-58-4
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem