Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Chernyshov, Vladimir V., once mentioned the application of 6674-22-2, Name is 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine, molecular formula is C9H16N2, molecular weight is 152.2367, MDL number is MFCD00006930, category is benzoxazole. Now introduce a scientific discovery about this category, SDS of cas: 6674-22-2.
Unexpected Ring Opening During the Imination of Camphor-Type Bicyclic Ketones
A new ring opening reaction was found while attempting to isolate the imines from ortho-heteroatom substituted anilines and camphor-like bicyclic ketones. The benzoazoles containing a cyclopentanemethyl group at position 2 of the heterocycle were isolated instead of the expected imines. The detailed study of the transformation, including EPR experiments, revealed the most probable radical mechanism. The proposed reaction pathways were confirmed by quantum chemical calculations. The dichotomy of 1-2 and 2-3 bonds cleavage is discussed together with the evaluation of the stereochemical outcome of the reactions. The benzoazoles obtained via the new reaction are of particular interest for the medicinal chemistry.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem