In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470), published in 2016-12-22, which mentions a compound: 96651-85-3, mainly applied to GPR40 agonist diabetes, Category: benzoxazole.
The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Hypothesis driven structural modifications to endogenous FFAs, focused on breaking planarity and reducing lipophilicity, led to the identification of spiropiperidine and tetrahydroquinoline acid derivatives as GPR40 agonists with unique pharmacol., selectivity and pharmacokinetic properties. Compounds 1 (LY2881835), 2 (LY2922083) and 3 (LY2922470) demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclin. testing. A clin. study with 3 administered to subjects with T2DM provided proof of concept of 3 as a potential glucose-lowering therapy. This manuscript summarizes the scientific rationale, medicinal chem., preclin. and early development data of this new class of GPR40 agonists.
If you want to learn more about this compound(2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride)Category: benzoxazole, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(96651-85-3).
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem