Synthesis of 2-(benzylthio)benzimidazole, 2-[(benzimidazol-2-yl)methylthio]benzimidazole and structural analogues against Haemonchus contortus was written by Akpa, Sagne Jacques;Say, Martial Venance;Zoakouma, Roger Simplice Pepin;Fante, Bamba;Sissouma, Drissa;Adjou, Ane. And the article was included in African Journal of Pharmacy and Pharmacology in 2016.Synthetic Route of C8H7NOS This article mentions the following:
The coupling of 2-mercaptobenzimidazoles with (chloromethyl)benzene derivatives gave 2-(benzylthio)benzimidazoles I (R1 = H, NO2, C6H5CO; R2 = H, 4-Cl, 3-NO2, 2,4-Cl) on one hand, and coupling with the 2-(chloromethyl)benzimidazoles on the other gave 2-[(benzimidazolyl)methylthio]benzimidazoles and analogs II (R4 = H, 6-CH3, 5-NO2, etc.; R3 = H, NO2, C6H5CO; X = NH, S, O). The evaluation of the anthelmintic activities of these mols. on Haemonchus contortus showed that the introduction of the nitro group (NO2) in the structure causes a significant increase of the activity. Among the mols. evaluated in vitro for their anti-infectious activity, compounds I (R1 = H; R2 = 3-NO2) and II (R1 = 5-NO2, 5-C6H5CO; R2 = H, NO2, C6H4CO) revealed an activity which is comparable to that of the reference mols. (ivermectin and fenbendazole). In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Synthetic Route of C8H7NOS).
6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Synthetic Route of C8H7NOS
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem