One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes was written by Aksenov, Nicolai A.;Aksenov, Alexander V.;Nadein, Oleg N.;Aksenov, Dmitrii A.;Smirnov, Alexander N.;Rubin, Michael. And the article was included in RSC Advances in 2015.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:
A one-pot cascade transformation involving metal-free and oxidant-free direct ortho-C-H functionalization, followed by Beckman rearrangement and intramol. cyclocondensation to produce benzoxazoles I [R1 = H, Me, Et, i-Pr, OH; R2 = H, Me, OH, F; R3 = H, Me; R4 = CH3, CH2CH3, (CH2)4CH3, C6H5, C6H5CH2] and benzobisoxazoles II (R5 = CH3, C6H5CH2; R6 = H, Me) directly from easily available phenols and PPA-activated nitroalkanes. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 2,5-Dimethylbenzoxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem