Altintop, Mehlika Dilek; Akalin Ciftci, Gulsen; Temel, Halide Edip published the artcile< Synthesis and evaluation of new benzoxazole derivatives as potential antiglioma agents>, HPLC of Formula: 13451-78-0, the main research area is benzoxazole based hydrazone preparation human apoptosis pharmacokinetics antiglioma.
New benzoxazole-based hydrazone derivatives I [R = H, F, Ph, etc.] were designed, synthesized and investigated against cytotoxic effects on C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines using MTT assay. The apoptotic effects of the most selective anticancer agent were analyzed based on Annexin V-PI binding capacities in flow cytometry. The compounds I were also investigated for their acetylcholinesterase (AChE) inhibitory effects using a modification of Ellman’s spectrophotometric method. In order to evaluate the compliance of the compounds to Lipinski’s rule of five, their physicochem. parameters were determined using Molinspiration software. Compound I [R = Ph] was found to be more effective on C6 cell line (IC50 = 4.30 ± 0.28 μg/mL) than mitoxantrone (IC50 = 4.56 ± 1.24 μg/mL). The high SI value of compound I [R = Ph] indicated that its antiglioma activity was selective. This compound caused late apoptosis in a dose dependent manner. Compound I [R = Ph] was also found to be the most effective AChE inhibitor in this series. According to in silico studies, compound I [R = Ph] only violated one parameter of Lipinski’s rule of five. On the basis of Lipinski’s rule, the compound was expected to have reasonable oral bioavailability.
Marmara Pharmaceutical Journal published new progress about Antitumor agents. 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, HPLC of Formula: 13451-78-0.
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem