Synthesis of Benzazoles through Electrochemical Oxidative Cyclization Reactions was written by An, Qi;He, Chaoyin;Fan, Xiaodong;Hou, Chuanfu;Zhao, Jian;Liu, Yue;Liu, Hao;Ma, Junjie;Sun, Zhizhong;Chu, Wenyi. And the article was included in ChemElectroChem in 2020.Synthetic Route of C13H8BrNO This article mentions the following:
An effective method for the synthesis of benzazoles through the electrochem. oxidative cyclization of o-aminophenol/o-aminothiophenol/o-phenylenediamine and aldehydes was developed. A series of benzazoles were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of the drug thiabendazole in a gram-scale reaction, which proved the practicality of the method. This approach avoids using catalysts and oxidants and has the advantages of wide substrate range, mild reaction conditions and good tolerance of functional groups. Finally, the possible reaction mechanism was proposed and supported by cyclic voltammetry (CV) and control experiments In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C13H8BrNO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem