Analyzing the synthesis route of 1086378-35-9

With the synthetic route has been constantly updated, we look forward to future research findings about Methyl benzo[d]oxazole-7-carboxylate,belong benzoxazole compound

As a common heterocyclic compound, it belong benzoxazole compound,Methyl benzo[d]oxazole-7-carboxylate,1086378-35-9,Molecular formula: C9H7NO3,mainly used in chemical industry, its synthesis route is as follows.,1086378-35-9

A solution of methyl benzo[d]oxazole-7-carboxylate (0.5 g, 2.82 mmol), 1-iodo-4-nitrobenzene (0.88 g, 3.53 mmol), lithium tert-butoxide (0.45 g, 5.64 mmol), tetrakis(triphenyl phosphine)palladium(0) (0.16 g, 0.141 mmol) in dioxane under a nitrogen atmosphere was stirred at room temperature for 45 minutes. The resulting thick suspension was diluted with EtOAc, washed with water, organics washed with brine, dried over Na2SO4, decanted and solvent removed under vacuum. The crude was purified by column chromatography on silica gel using 20:1 to 5:1 Hexane:EtOAc as eluent to give methyl 2-(4-nitrophenyl)benzo[d]oxazole-7-carboxylate (0.4 g, 48%). UPLC-MS (Acidic Method, 2 min): rt 1.11 min, m/z 299.0 [M+H]+

With the synthetic route has been constantly updated, we look forward to future research findings about Methyl benzo[d]oxazole-7-carboxylate,belong benzoxazole compound

Reference£º
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R.; GRAHAM, Mark; (46 pag.)WO2020/43880; (2020); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem