Analyzing the synthesis route of 1750-45-4

1750-45-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1750-45-4 ,5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, and cas is 1750-45-4, its synthesis route is as follows.

6-Hydroxy-5-chlorobenzo [d] oxazol-2 (3H) -one(1.8 g, 10 mmol),3-Bromomethyl-2H-1,2,3-triazole (1.8 g, 11 mmol),A mixture of potassium carbonate (2.8 g, 20 mmol) in acetonitrile (200 mL) was stirred at 70 C for 16 h,The solvent was removed in vacuo and the residue was purified by column chromatography on silica gel eluting with petroleum ether / ethyl acetate 20: 1,To give 3 – [(2H- 1,2,3 -triazol-2-yl) methyl) -5-chloro-6- hydroxybenzo [d] oxazol-2 (3H) -one as an orange solid (2.3 g, 85%)

1750-45-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1750-45-4 ,5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, other downstream synthetic routes, hurry up and to see

Reference:
Patent; Mudanjiang Medical School; Li Hailin; Wang Wei; Song Jing; Sun Zhiguo; Han Guangyu; (12 pag.)CN106928212; (2017); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem