Analyzing the synthesis route of 19219-99-9

With the synthetic route has been constantly updated, we look forward to future research findings about 5-Chloro-2-methylbenzo[d]oxazole,belong benzoxazole compound

As a common heterocyclic compound, it belong benzoxazole compound,5-Chloro-2-methylbenzo[d]oxazole,19219-99-9,Molecular formula: C8H6ClNO,mainly used in chemical industry, its synthesis route is as follows.,19219-99-9

Preparative Example 3; Step A; Commercially available 5-chloro-2-methylbenzoxazole (1.5 g), potassium cyanide (612 mg), dipiperidinomethane (720 muL), palladium diacetate (80 mg) and 1,5-bis-(diphenylphosphino)pentane (315 mg) were dissolved in dry toluene (20 mL), degassed and stirred at 160 C. in a sealed pressure tube under argon. After 24 h the mixture was diluted with ethyl acetate. The organic layer was washed with saturated ammonium chloride and brine, dried (MgSO4), concentrated and purified by column chromatography (silica, cyclohexane/EtOAc, 9:1 to 7:3) to afford the intermediate (372 mg; 26%) as a colourless solid. 1H-NMR (CDCl3) delta=2.63 (s, 3H), 7.48-7.58 (s, 2H), 7.90 (s, 1H).

With the synthetic route has been constantly updated, we look forward to future research findings about 5-Chloro-2-methylbenzo[d]oxazole,belong benzoxazole compound

Reference£º
Patent; ALANTOS PHARMACEUTICALS, INC.; US2007/155739; (2007); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem