54903-16-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2-Oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid, cas is 54903-16-1,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Method E: A solution of the appropriate acid 3a (0.91 g, 5.1 mmol) inchloroform (20 mL) was cooled to 0 C with stirring. Thionyl chloride(1.75 mL, 24 mmol) was added dropwise, and the reaction mixture was heated at reflux for 5 h. After evaporation, the resulting crude acid chloride was dissolved in dichloromethane (50 mL),to 4 C, and added dropwise to a cooled mixture of 2-amino-4,6-dimethylpyridine(0.51 g, 4.8 mmol) and triethylamine (0.95 mL, 6.8 mmol) in dichloromethane (50 mL). The reaction mixture was then stirred at room temperature for 18 h. After evaporation of dichloromethane under vacuum, the residue was treated with water and the resulting precipitate filtered, washed with water, dried and recrystallised from 95% ethanol. Compound (4b) was synthesised in an identical fashion to (4a).
The chemical industry reduces the impact on the environment during synthesis,54903-16-1,2-Oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid,I believe this compound will play a more active role in future production and life.
Reference：
Article; Messaoud, Liacha; Wassila, Yahia; Khemissi, Seddiki; Yasmina, Adjeroud; Hanane, Chabane; Journal of Chemical Research; vol. 38; 6; (2014); p. 331 – 333;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem