As a common heterocyclic compound, it belong benzoxazole compound,2,5-Dichlorobenzooxazole,3621-81-6,Molecular formula: C7H3Cl2NO,mainly used in chemical industry, its synthesis route is as follows.,3621-81-6
To a solution of 2,5-dichlorobenzo[d]oxazole (5 g, 26.6 mmol) in dry dichloromethane (50 ml_) was added 2M dimethylamine in THF (26.6 mL, 53.2 mmol), and the mixture was cooled to 0C. To this cold reaction mixture was added triethylamine (5.6 mL, 39.9 mmol) drop-wise and the mixture was allowed to stir at room temperature for 4 h. After the completion of the reaction, the reaction mixture was treated with H20 (2 x 20 mL) and extracted with dichloromethane. The organic layer was separated, dried over Na2S04, filtered and evaporated to afford a white solid which was triturated with diethyl ether to afford the titlecompound (4.9 g, 94 %). (0493) MS: 197.2 (M+H)+. (0494) 1H-NMR (400 MHz, DMSO-c/6) d = 7.40 (d, J = 8.40 Hz, 1 H), 7.30 (d, J = 2.00 Hz, 1 H), 6.99- 6.99 (m, 1 H), 3.13 (s, 6H).
With the synthetic route has been constantly updated, we look forward to future research findings about 2,5-Dichlorobenzooxazole,belong benzoxazole compound
Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem