5676-60-8,5676-60-8, 2-Methylbenzo[d]oxazol-6-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4n-propylbenzenesulphonyl chloride (163 mg, 0.744 MMOL) in dichloromethane (3 mL) was added pyridine (140 uL, 1.72 MMOL) and the mixture was stirred under N2 for 5 min, after which time 6-AMINO-2-METHYLBENZOXAZOLE (105 mg, 0.709 MMOL) was added. The resulting mixture was stirred for 1 h at room temperature, then saturated NAHC03 solution was added (8 mL) and the mixture was extracted into ethyl acetate (15 mL). The organic phase was washed with brine, dried (NA2SO4), filtered and evaporated to give a residue that was purified using flash chromatography to afford a pale pink solid (164 mg, 70%), single spot at Rf 0.49 (60: 40 hexane: ethyl acetate). mp 101.7-102. 3C, HPLC purity 99% (tR 2.02 min in 10% water-acetonitrile). ‘H NMR (CDCI3) : 6 7.61 (2H, m), 7.43 (1H, d, J=8.4 Hz), 7.37 (1H, d, J=1. 8 Hz), 7.19 (2H, m), 6.83 (2H, m), 2.57 (5H, m), 1.58 (2H, sextet, J=7.3 Hz), 0.88 (3H, t, J=7.3 Hz). LCMS: 329.21 (M-). FAB-MS (MH+, C17H18N203S) : calcd 331.1116, found 331.1107.
5676-60-8 2-Methylbenzo[d]oxazol-6-amine 590539, abenzoxazole compound, is more and more widely used in various fields.
Reference£º
Patent; STERIX LIMITED; WO2004/37251; (2004); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem